Mister Sinister

Team synergies(4)

Genetic Masterpiece

UNIQUE

Cable

• All Mutants: Randomly start the fight with either +25% passive Attack Rating, +25% passive Power Rate, or +25% passive Armor Rating.

Mutant Dominion

UNIQUE

Magneto

Magneto (House of X)

• All Mutants: Gain +20% Passive Fury when fighting with Class Disadvantage.

Bloodlines

UNIQUE

Cyclops (New Xavier School)

Cyclops (Blue Team)

Phoenix

• Mister Sinister, Cyclops (Blue Team), Cyclops (New xavier School), Phoenix: Special Attacks have +20% Critical Rating and gain True Strike, ignoring all Armor, Resistances, Evasion, and Auto Block.

Masterminds

UNIQUE

M.O.D.O.K.

Kingpin

Ultron

• Mister Sinister, Kingpin, Ultron, M.O.D.O.K.: Each time the opponent uses a Special Attack they become Power Locked for 6 seconds.

You enable for other champions(13)

Bringing this champion enables the following synergies for other champions in your team. The host's effect text is shown so you can see what benefit the pairing unlocks.

Your Fate Is Mine

UNIQUE

Benefit for Apocalypse

Mister Sinister

Kang

Cable

• Apocalypse: Start the first fight in a quest with maximum Genetic Code.
• Kang: Every 4 seconds, Kang Gains an indefinite Fury Buff granting 20% Attack Rating. This ends when reaching 20 stacks of Fury.
• Mister Sinister: Degeneration Debuffs gain +50% Potency.
• Cable: Incinerate Debuffs gain +150% Potency. Additionally, Heavy Attacks now inflict Degeneration on each hit and their stack limit is removed.

Geneticists

UNIQUE

Benefit for Arnim Zola

Mister Sinister

• Arnim Zola: Personal Disintegration Debuffs deal 20% more damage.
• Mister Sinister: Personal Degeneration Debuffs deal 20% less damage but gain 50% increased duration.

Enemies

Benefit for Colossus

Hyperion

Mister Sinister

Magneto

• All Champions gain +[155] Critical Rating.

Peak Fashion

UNIQUE

Benefit for Count Nefaria

Doctor Strange

Iron Fist

Mister Sinister

Gladiator

• Synergy Champions: Block Proficiency increased by +[400].

Enemies

Benefit for Gambit

Magneto

Apocalypse

Mister Sinister

• All Champions gain +[155] Critical Rating.

Runs in the Family

UNIQUE

Benefit for Havok

Cyclops (Blue Team)

Cyclops (New Xavier School)

Mister Sinister

• Havok: Gain 2 Plasma Charge(s) after each Special Attack.
• Mister Sinister: Well timed Blocks against contact attacks inflict Degeneration, dealing 30% of Attack as Direct Damage over 1 second(s).
• Cyclops (Blue Team), Cyclops (New Xavier School): Armor Break effects increase their Duration by 100%.

Rivals

Benefit for Kingpin

Mister Sinister

M.O.D.O.K.

Ultron

Loki

• All Champions gain +[115] Critical Damage Rating.

Crazy Scientists

UNIQUE

Benefit for Lizard

M.O.D.O.K.

Mister Sinister

The Overseer

• Lizard: Personal Unstoppable lasts +2 seconds.
• M.O.D.O.K.: At the end of Special 1, inflict a non-stacking 100% Petrify Debuff for 4 seconds.
• Mister Sinister: When the Opponent fails to Purify one or more Debuffs due to reduced Ability Accuracy, self-inflict a personal Bleed Debuff.
• The Overseer: Against Mystic Champions, gain a Steadfast Passive while at or above 3 Gamma Power.

The Monster Who Created Me

UNIQUE

Benefit for Madelyne Pryor

Mister Sinister

• Synergy Champions: For each Madelyne Pryor on the team, inflict a 20% Hinder Debuff for 3 seconds at the start of each fight.

No More Patients

UNIQUE

Benefit for Sauron

Mister Sinister

Doctor Strange

• Sauron, Mister Sinister, Doctor Strange: Whenever an Opponent heals, gain a 2% Regen Passive for 2 seconds. This goes on Cooldown for 5 seconds. Once this has been triggered 4 times, Inflict Heal Block Passive for 12 seconds.

Enemies

Benefit for Storm

Magneto

Magneto (House of X)

Sentinel

Mister Sinister

• All Champions gain +[155] Critical Rating.

Enemies

Benefit for Stryfe

Havok

Mister Sinister

Beast

• All Champions gain +[155] Critical Rating.

Intelligencia Old and New

Benefit for The Leader

M.O.D.O.K.

Doctor Doom

Mister Sinister

• All Champions gain 5% Perfect Block Chance.